제품소개
Dextran Sulfate Sodium Salt
Mpbio
작성자
pengwing
작성일
2020-01-06 11:30
조회
106
Dextran Sodium Sulfate
CAS Number 9011-18-1
Molecular Weight 36,000-50,000
MDL Number MFCD00081551
Product Description
Dextran sulfate is a polyanionic derivative of dextranproduced by esterification of Dextran with chlorosulphonic acid. Dextransulfate sodium (DSS) is the sodium salt which is a white to off-white powderfreely soluble in water and salt solutions to form a stable, clear solution.The sulfur content is approximately 17% which corresponds to an average of1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran is apolymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166)linkages. The remaining (163) linkages account for the branching of dextran.
Applications
DextranSulfate Sodium (DSS) which has proven to have versatile value inBiomedical/clinical research. DSS can be used to study Colitis (InflammatoryBowel disease) as well as an antiviral as agent.
Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsinginflammation of the gastrointestinal tract which is associated with increasedrisk of developing colitis-associated cancer. Several animal models have beenused to study colitis and one such model involves the oral administration ofdextran sodium sulfate (DSS) in the drinking water of mice leading to chroniccolitis. This DSS induced colitis model is spontaneous and is used to assessthe therapeutic potential of treatments for IBD.
Bamba et al (2012) performed a comparative analysis of 3 different DSSpreparations to examine the chemical and cytotoxic properties as well asseverity of colitis. Their study concluded that the DSS from MP Biomedicalsinduced a severe colitis as indicated by body weight transition, DAI score,colon weight/length and histological scores. This DSS is well characterizedand offers the following advantages:
• Highest sulfur content – 19%
• Highest chirality - +104° of specific rotation
• Lowest pH – 6.2 at 1% solution